Endocrine Abstracts

ObjectiveTo investigate whether salivary cortisol could provide an alternative to serum cortisol for hypocortisolaemic patients undergoing hydrocortisone day curves.MethodCorrelational study of 58 patients receiving corticosteroid replacement therapy for primary (9) or secondary (49) hypocortisolaemia. Paired samples of saliva and serum were taken at pre-determined time points throughout a 7½ hour hydroc...

Mitotane (o,p’DDD) is commonly used for the treatment of adrenocortical carcinoma (ACC), both for advanced disease and in the adjuvant setting. Mitotane induces adrenal insufficiency but specific effects on steroidogenic enzymes are unknown.We investigated 24-h urinary steroid metabolite excretion in ACC patients on adjuvant mitotane (AD) or mitotane for metastatic disease (MET). We compared samples collected before mitotane treatment (BEFORE; MET <...

Aim: To evaluate the effects of short and long-term treatment with PEG on rhythm disturbances in a cohort of acromegalic patients resistant to long-term high-dose therapy with SA.Patients and methods: Thirteen patients (4 M, 9 F, aged 44±9.25 years) entered the study. All patients started PEG at initial dose of 10 mg daily, then increased of 5 mg every 6 weeks on the basis of IGF1 levels, until IGF1 normalisation or until the achievement of the maxi...

The first patient with a catecholamine-secreting paraganglioma that was sucessfully resected was in 1926. Over the past 97 years, there has been a dramatic evolution in the clinical presentation, methods used to diagnose and localize, and germline genetic testing of paragangliomas (PGLs). When contrasted to adrenal pheochromocytoma, PGLs present the clinician with unique challenges, which include: 1) diverse location—they may be located anywhere from the tympanic membrane...

Both genetic and environmental factors determine whether individuals who have a predisposition to the development of type 1 diabetes actually develop the disease. Although we now know a considerable amount about the genetics through genome wide scans, and diabetes risk scores have been developed, the actual environmental triggers or perpetuating factors are not clearly defined. There has been considerable interest in recent years in investigation of these possible environmenta...

This practical and interactive session will explore the difficult clinical presentation of sweating.This problem is very commonly encountered in primary care, and can present a major diagnostic and management challenge. In practise, although there are multiple endocrine causes for excessive sweating, in the majority of cases presenting with this symptom alone, no endocrine cause is found.An overview of the most important aspects of...

Hirsutism is the presence of excessive terminal hair in androgen dependent areas of the female body. A frequent medical complaint that affects ∼ 12% of Caucasian premenopausal women, hirsutism usually results from relatively benign functional disorders. Among them, the polycystic ovary syndrome is the most frequent etiology.The most important tool for the diagnosis of hirsutism is a complete clinical history and physical examination. Functional cau...

Vitamin D deficiency has a leading role in endothelial functions and pathogenesis of type two diabetes and is supposed to take part in atherosclerosis. In this study we aimed to investigate the correlation between markers of atherosclerosis and inflammation with 25(OH)D levels in patients with type two diabetes. Forty patients with type two diabetes and macrovascular complication and 40 patients without macrovascular complication were included in the study. Thirty healthy subj...

Struma Ovarii and its malignant transformation to thyroid-type carcinoma are rare conditions. In recent reviews of reported literatures, only 53 cases of papillary thyroid-type carcinoma arising from struma ovarii were documented from 1924 to 2008. Due to the rarity of the disease, lack of uniform histological criteria for malignancy and protracted clinical course, its management is not also universally accepted by physicians. The aim of this paper is to present a very rare ca...

Accurate and sensitive detection of the biomarkers is important both for preclinical research fields such as biochemistry, biomedicine, and clinical diagnostics. Immunosensors are the miniaturized analytical devices that combine high specificity of immunological reaction with sensitivity of detection techniques.In this study, we developed a new competitive immunosensor with employing antibody (Ab) labeled AuNP (Ab-AuNP) and mobile crystalline material-41...